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Sacrifice

Sacrifice can be done in three ways: offering your own blood via the Sacrificial Knife, sacrificing mobs with the Dagger of Sacrifice, or right clicking with any blood orb in hand. Blood orbs do not benefit from altar upgrades, and go directly to your LP level.

The amount of LP gained by sacrifice can be increased by adding Rune of Sacrifice (when sacrificing mobs) or Rune of Self-Sacrifice (for using the Sacrificial Knife) to the Blood Altar pyramid.