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The main article can be found at Minecraft Wiki: Ender Pearl.
It can be thrown to teleport the player to its landing point at the cost of 2.5 hearts. When combined with Blaze Powder, an Eye of Ender is created. These are used to find and activate the Ender Portal in strongholds.
The Ender Pearl can be smelted in a Furnace to yield 8 Ender Pearl Dust (Portal Gun Mod). These combined with a Nether Star make a Miniature Black Hole; a necessary ingredient in the Portal Gun.
With GregTech installed, it can be processed in a Macerator (or equivalent device) to get Ender Pearl Dust (GregTech). This is not interchangeable with the Portal Gun version. This dust can then be electrolyzed to separate it into a variety of elements.
This recipe requires 2500 MJ or 20000 RF.